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Safety data sheet. GHS / OSHA HCS 2012 format, 16 sections. Issued by Epic Peptides Lab for the catalogue items listed in Section 1.

Epic Peptides Lab

Safety data sheet · lyophilized powder, vial

Epic Peptides Lab · USA

Document number
PL-SDS-082
Revision
1.0 · 2026-10-03

HMG (Menotropins)

lyophilized powder, vial

DANGER

1Identification

Product Identifier
HMG (Menotropins)
Document Number
PL-SDS-082
Catalogue Items Covered
  • Id
    2230
    Name
    HMG 75IU
    Sku
    PL-HMG-75IU-VIAL
Recommended Use
Laboratory research use by trained personnel.
Restrictions On Use
Not for human or veterinary use.
Supplier / Distributor
Epic Peptides Lab, USA
Telephone
+1 (787) 468-5291
Email
info@epicpeptideslab.com

2Hazard(s) identification

Classification
  • Reproductive toxicity — Category 1B — H360
  • Specific target organ toxicity, repeated exposure — Category 1 — H372
Label Elements
Pictograms
  • GHS08
Signal
Danger
Hazard statements
  • H360 May damage fertility or the unborn child.
  • H372 Causes damage to organs (reproductive organs) through prolonged or repeated exposure.
Precautionary statements
  • P201 Obtain special instructions before use.
  • P202 Do not handle until all safety precautions have been read and understood.
  • P260 Do not breathe dust, mist or spray.
  • P264 Wash hands and any exposed skin thoroughly after handling.
  • P270 Do not eat, drink or smoke when using this product.
  • P280 Wear protective gloves, protective clothing and eye protection.
  • P308+P313 IF exposed or concerned: Get medical advice/attention.
  • P314 Get medical advice/attention if you feel unwell.
  • P405 Store locked up.
  • P501 Dispose of contents and container to an approved waste disposal plant in accordance with local, state and federal regulations.
Signal Word
Danger
Other Hazards
No data available.

3Composition / information on ingredients

Description
Lyophilized (freeze-dried) powder or cake in a sealed glass vial with a rubber stopper and aluminium crimp cap.
Composition
  • Name
    HMG (Menotropins)
    Full
    Human menopausal gonadotropin: urinary FSH and LH; potency assigned in IU by bioassay
    Cas
    61489-71-2
    Formula
    Not applicable (glycoprotein mixture)
    Conc
    ≥ 95% (dry basis, as supplied)
    Qty
    75 IU per vial
    Hazards
    • Reproductive toxicity — Category 1B — H360
    • Specific target organ toxicity, repeated exposure — Category 1 — H372

4First-aid measures

First Aid Measures
Inhalation
Move the person to fresh air and keep comfortable for breathing. If breathing is difficult or symptoms persist, call a POISON CENTER or doctor.
Skin
Take off contaminated clothing. Wash the skin with plenty of soap and water. If irritation or a rash develops, get medical advice.
Eyes
Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do; continue rinsing. If eye irritation persists, get medical advice.
Ingestion
Rinse mouth. Do not induce vomiting. Call a POISON CENTER or doctor if you feel unwell.
General
If exposed or concerned, get medical advice. Show this safety data sheet to the doctor. Pregnant or nursing laboratory staff should avoid exposure.
Most Important Symptoms And Effects
No specific symptoms are known. Pharmacologically active material: systemic effects consistent with its mechanism of action are possible after accidental injection, ingestion or absorption.
Likely Routes Of Exposure
Inhalation of dust, skin and eye contact when the vial is opened or the powder is weighed; ingestion through contaminated hands; accidental injection when reconstituted solutions are drawn into syringes.

5Fire-fighting measures

Fire Fighting Information
Combustible organic solid; finely divided powder may form dust clouds. Not flammable in the quantities supplied.

6Accidental release measures

Spill And Clean Up Procedures
Avoid dust formation. Dampen spilled powder with water, wipe up with absorbent material, place in a sealed container for disposal and clean the area with water and detergent.

7Handling and storage

Safe Handling
Open vials only in a clean area. Avoid generating or inhaling dust; weigh or reconstitute inside a ventilated enclosure when the full contents are handled as a dry powder. Reconstitute by adding diluent slowly to the vial wall; do not shake. Wash hands after handling.
Safe Storage
Store the sealed vial at the temperature stated in Section 9 (typically −20 °C for peptides, 2–8 °C for proteins), desiccated and protected from light. Allow the vial to reach room temperature before opening to avoid condensation. Reconstituted solutions: 2–8 °C, protected from light; use within the period established by your laboratory.
Storage Temperature
2–8 °C (sealed vial); −20 °C for long-term storage; protected from light and moisture
Incompatible Materials
Heat and moisture

8Exposure controls / personal protection

Occupational Exposure Limits
No data available.
Exposure Controls And PPE
No data available.

9Physical and chemical properties

Physical State
Solid
Appearance
White to off-white lyophilized powder or cake
Properties
Odor
Little to none (ProSpec)
Ph
Not applicable (solid); aqueous solutions typically pH 4–7
Melting
Not available (protein; denatures rather than melts)
Boiling
Not applicable
Flash
Not applicable (non-flammable solid); combustible organic material
Vapour
Negligible (solid)
Density
No data available (bulk density of lyophilized cake is low)
Solubility
Soluble in water; reconstitute in sterile water at not less than 100 µg/ml (ProSpec); pharmaceutical product reconstituted in 0.9% NaCl
Logp
Not applicable
Decomp
No data available; peptides decompose above about 200 °C
Other
Glycoprotein mixture of urinary FSH and LH (hCG-driven LH activity in pharmaceutical product), FSH ~30 kDa, LH ~28.5 kDa; potency assigned in IU by bioassay (ProSpec: 100 IU/mg FSH and 100 IU/mg LH).

10Stability and reactivity

Stability And Reactivity
Reactivity
Stable under recommended storage and handling temperatures (ProSpec)
Incompatible
Heat and moisture; strong acids/alkalis, strong oxidizing/reducing agents (ProSpec)
Decomposition
In combustion may emit toxic fumes (ProSpec); carbon oxides, nitrogen oxides, sulfur oxides expected
Conditions To Avoid
Heat, moisture, freeze-thaw cycles, dust formation (MSD: gonadotropin powders may form explosive dust-air mixtures during processing)
Conditions To Avoid
Heat, moisture, freeze-thaw cycles, dust formation (MSD: gonadotropin powders may form explosive dust-air mixtures during processing)
Incompatible Materials
Heat and moisture

11Toxicological information

Toxicological Information
  • Acute toxicity, oral

    No data available for hMG. Analogue data: serum gonadotrophin (PMSG) oral LD50 mouse 120 mg/kg (MSD SDS) - analogue only, do not transfer to hMG

  • Acute toxicity, dermal

    No data available

  • Acute toxicity, inhalation

    No data available

  • Skin corrosion/irritation

    Not available (ProSpec). MSD gonadotropin SDS: possible allergic reaction on skin contact

  • Serious eye damage/irritation

    Not available

  • Respiratory or skin sensitisation

    Not available (ProSpec). Human urine-derived glycoprotein - allergic/hypersensitivity reactions are described in the Menopur prescribing information; MSD gonadotropin SDS lists allergic reactions on inhalation

  • Germ cell mutagenicity

    Not available

  • Carcinogenicity

    Not listed by IARC, NTP or OSHA

  • Reproductive toxicity

    Not available (ProSpec). Pharma analogues: Organon recombinant FSH formulation Repr. 1B H360FD (reduced estrous cycles, embryonic resorptions in rats/rabbits); MSD PMSG Repr. 1B H360Fd (LOAEL 10 µg/kg s.c., rat fertility); MSD hCG Repr. 1A (LOAEL 0.224 mg/kg, monkey fertility).

  • STOT, single exposure

    Not available

  • STOT, repeated exposure

    Not available for hMG. Analogues: STOT RE 1 (ovary) H372 for hCG/PMSG and rFSH formulations (MSD, Organon)

  • Aspiration hazard

    Not available

Routes Of Exposure
Inhalation of dust, skin and eye contact when the vial is opened or the powder is weighed; ingestion through contaminated hands; accidental injection when reconstituted solutions are drawn into syringes.
Symptoms
No specific symptoms are known. Pharmacologically active material: systemic effects consistent with its mechanism of action are possible after accidental injection, ingestion or absorption.

12Ecological information

Ecological Information
Not available (ProSpec). No ecotoxicity data for gonadotropins in any SDS reviewed; proteins are readily biodegradable in principle.

13Disposal considerations

Disposal Guidance
No data available.

14Transport information

Transport Classification
Note
Not regulated as a dangerous good for transport by road (DOT 49 CFR), air (IATA/ICAO) or sea (IMDG). Not a marine pollutant. Ship refrigerated or frozen as required by Section 7; the coolant (dry ice, UN 1845) is regulated when used.

15Regulatory information

Regulatory Information
Tsca
Not applicable / not listed (ProSpec: TSCA not applicable; biological)
Carcinogen Listings
Not listed by IARC, NTP, OSHA; not Prop 65 listed
Dea
Not a controlled substance (gonadotropins are not DEA-scheduled)
Other
Menotropins is an FDA-approved prescription biologic (Menopur, Ferring; 75 IU FSH / 75 IU LH activity per vial). Human urine-derived: ProSpec product tested negative for HBsAg, anti-HIV and anti-HCV - biological-origin statement belongs in SDS. WADA remark: FSH, LH and hCG are prohibited for males under S2.2 of the WADA Prohibited List.
Carcinogen Listings
No data available.

16Other information

Revision
October 3, 2026
Sources Consulted
  • ProSpec-Tany TechnoGene
  • ProSpec product page
  • Organon
  • MSD Animal Health
Confidence
medium
Additional Information
  • Lyophilised recombinant or purified protein. Inhalation of protein dusts can sensitise susceptible individuals; avoid generating dust and handle the dry powder in a ventilated enclosure. Not classified for respiratory sensitisation because no substance-specific data exist.
  • Derived from animal tissue or human urine. Sourced and processed to minimise adventitious-agent risk; handle with standard biological precautions.
  • WADA Prohibited List class S2.2.
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