Safety data sheet. GHS / OSHA HCS 2012 format, 16 sections. Issued by Epic Peptides Lab for the catalogue items listed in Section 1.

Epic Peptides Lab

Safety data sheet · solution, metered nasal spray

Epic Peptides Lab · USA

Document number: PL-SDS-075
Revision: 1.0 · 2026-10-03

Gonadorelin

solution, metered nasal spray

DANGER

1Identification

Product Identifier

Gonadorelin

Document Number

PL-SDS-075

Catalogue Items Covered

Id
15825
Name
Gonadorelin 10mg Nasal Spray
Sku
PL-GONADORELIN-10MG-NS

Recommended Use

Laboratory research use by trained personnel.

Restrictions On Use

Not for human or veterinary use.

Supplier / Distributor

Epic Peptides Lab, USA

Telephone

+1 (787) 468-5291

info@epicpeptideslab.com

2Hazard(s) identification

Classification

Respiratory sensitisation — Category 1 — H334
Reproductive toxicity — Category 2 — H361
Specific target organ toxicity, repeated exposure — Category 2 — H373

Label Elements

Pictograms: GHS08
Signal: Danger
Hazard statements: H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled.

H361 Suspected of damaging fertility or the unborn child.

H373 May cause damage to organs (reproductive organs) through prolonged or repeated exposure.
Precautionary statements: P201 Obtain special instructions before use.

P202 Do not handle until all safety precautions have been read and understood.

P260 Do not breathe dust, mist or spray.

P261 Avoid breathing dust, mist or spray.

P280 Wear protective gloves, protective clothing and eye protection.

P284 In case of inadequate ventilation wear respiratory protection.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P308+P313 IF exposed or concerned: Get medical advice/attention.

P314 Get medical advice/attention if you feel unwell.

P342+P311 If experiencing respiratory symptoms: Call a POISON CENTER or doctor.

P405 Store locked up.

P501 Dispose of contents and container to an approved waste disposal plant in accordance with local, state and federal regulations.

Signal Word

Danger

Other Hazards

No data available.

3Composition / information on ingredients

Description

Sterile aqueous solution in bacteriostatic water (0.9% benzyl alcohol), supplied in a metered-dose nasal spray bottle.

Composition

Name
Gonadorelin
Full
Native gonadotropin-releasing hormone (GnRH, LHRH)
Cas
33515-09-2
Formula
C55H75N17O13
Conc
≤ 0.1% w/v
Qty
10 mg per bottle
Hazards
- Reproductive toxicity — Category 2 — H361
- Specific target organ toxicity, repeated exposure — Category 1 — H372
- Respiratory sensitisation — Category 1 — H334
- Skin sensitisation — Category 1 — H317
- Acute toxicity, inhalation — Category 4 — H332
Name
Benzyl alcohol (preservative)
Full
Benzyl alcohol, antimicrobial preservative (0.9% w/v in bacteriostatic water)
Cas
100-51-6
Formula
C7H8O
Conc
0.9% w/v
Hazards
- Acute toxicity, oral — Category 4 — H302
- Acute toxicity, inhalation — Category 4 — H332
- Serious eye damage/eye irritation — Category 2A — H319
- Skin sensitisation — Category 1B — H317
Name
Water for injection
Full
Water for injection
Cas
7732-18-5
Formula
H2O
Conc
balance to 100%

4First-aid measures

First Aid Measures

Inhalation: Move the person to fresh air and keep comfortable for breathing. If breathing is difficult or symptoms persist, call a POISON CENTER or doctor. If experiencing respiratory symptoms (wheezing, shortness of breath), call a POISON CENTER or doctor.
Skin: Take off contaminated clothing. Wash the skin with plenty of soap and water. If irritation or a rash develops, get medical advice.
Eyes: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do; continue rinsing. If eye irritation persists, get medical advice.
Ingestion: Rinse mouth. Do not induce vomiting. Call a POISON CENTER or doctor if you feel unwell.
Injection: For an accidental needle-stick: wash the site with soap and water, do not squeeze, cover with a dressing and seek medical advice; report the incident according to your laboratory's sharps procedure.
General: If exposed or concerned, get medical advice. Show this safety data sheet to the doctor. Pregnant or nursing laboratory staff should avoid exposure.

Most Important Symptoms And Effects

wheezing, chest tightness or asthma-like symptoms after inhalation in sensitised individuals.

Likely Routes Of Exposure

Inhalation of the aerosol and absorption through the nasal mucosa are the intended laboratory routes; eye contact from mis-directed spray; skin contact.

5Fire-fighting measures

Fire Fighting Information: Aqueous solution containing 0.9% benzyl alcohol; not flammable and does not support combustion.

6Accidental release measures

Spill And Clean Up Procedures: Absorb small spills with paper towel or an inert absorbent, place in a sealed container for disposal and clean the area with water and detergent.

7Handling and storage

Safe Handling: Avoid spraying toward the eyes or face. Do not share devices. Wipe the nozzle after use and keep the cap on. Wash hands after handling.
Safe Storage: Store at 2–8 °C, protected from light; do not freeze. Keep upright and capped.
Storage Temperature: 2–8 °C, protected from light; do not freeze
Incompatible Materials: Bases and strong acids (PolyPeptide); strong oxidizing agents (generic)

8Exposure controls / personal protection

Occupational Exposure Limits: Benzyl alcohol: no OSHA PEL, ACGIH TLV or NIOSH REL; AIHA WEEL 10 ppm (44 mg/m³) 8-h TWA. Present at 0.9%.

No occupational exposure limits have been established for the active ingredient(s).
Exposure Controls And PPE: No data available.

9Physical and chemical properties

Physical State

Liquid

Appearance

Clear, colourless to faintly yellow aqueous solution

Properties

Odor: Odourless to faint aromatic odour (benzyl alcohol)
Ph: Approximately 4.5–7.0 (bacteriostatic water, USP) unless adjusted
Melting: About 0 °C (aqueous solution)
Boiling: About 100 °C (aqueous solution)
Flash: Not flammable; aqueous solution (benzyl alcohol flash point 93–101 °C, present at 0.9%)
Vapour: As water (about 2.3 kPa at 20 °C)
Density: About 1.00–1.02 g/mL at 20 °C
Solubility: Aqueous solution; miscible with water
Logp: No data available
Decomp: Not applicable (aqueous solution); dissolved peptide degrades on heating

10Stability and reactivity

Stability And Reactivity

Reactivity: Stable under normal conditions; decomposes slowly in aqueous solutions; combustible; dust may form explosive mixture with air (PolyPeptide). No decomposition if used according to specifications (Cayman)
Incompatible: Bases and strong acids (PolyPeptide); strong oxidizing agents (generic)
Decomposition: Carbon and nitrogen oxides (PolyPeptide); Cayman: no dangerous decomposition products known
Conditions To Avoid: Strong heat, light and moisture; avoid generation of dust (PolyPeptide). Store -20 °C (Cayman) or 2-8 °C/-20 °C desiccated

Conditions To Avoid

Strong heat, light and moisture; avoid generation of dust (PolyPeptide). Store -20 °C (Cayman) or 2-8 °C/-20 °C desiccated

Incompatible Materials

No data available.

11Toxicological information

Toxicological Information: Acute toxicity, oral
LD50 oral mouse >4,000 mg/kg; LD50 oral rat >3 g/kg (Cayman); LD50 oral rat >3,000 mg/kg (PolyPeptide)

Acute toxicity, dermal
No data available

Acute toxicity, inhalation
No LD50/LC50; PolyPeptide classifies Acute Tox. 4 inhalation (H332) on a precautionary basis for potent API dust

Skin corrosion/irritation
No irritant effect (Cayman)

Serious eye damage/irritation
No irritating effect (Cayman)

Respiratory or skin sensitisation
Cayman: no sensitizing effects known. PolyPeptide: Skin Sens. 1 and Resp. Sens. 1 (H317, H334) - peptide hormone, allergic reactions (including anaphylaxis) reported clinically

Germ cell mutagenicity
No data available

Carcinogenicity
Not listed by IARC, NTP or OSHA (Cayman, PolyPeptide)

Reproductive toxicity
Cayman: Repr. 2 (H361). ChemicalBook: Repr. 1 (H360). PolyPeptide: 'Gonadotropins may impair fertility and the unborn child. It may cause changes in sex hormones, reduced libido and abortion'; maternal/reproductive effects in rat studies

STOT, single exposure
No data available

STOT, repeated exposure
Cayman: STOT RE 1 (H372). PolyPeptide chronic effects: 'Gonadorelin is also found to cause osteoporosis' (via hypogonadism on chronic exposure)

Aspiration hazard
Not applicable
Routes Of Exposure: Inhalation of the aerosol and absorption through the nasal mucosa are the intended laboratory routes; eye contact from mis-directed spray; skin contact.
Symptoms: wheezing, chest tightness or asthma-like symptoms after inhalation in sensitised individuals.

12Ecological information

Ecological Information: Cayman: 'Water hazard class 1 (Self-assessment): slightly hazardous for water'. PolyPeptide: no available data on ecotoxicity, persistence, bioaccumulation or mobility. Endocrine-active peptide - avoid release to drains.

13Disposal considerations

Disposal Guidance: No data available.

14Transport information

Transport Classification

Note: Not regulated as a dangerous good for transport by road (DOT 49 CFR), air (IATA/ICAO) or sea (IMDG). Not a marine pollutant. Ship refrigerated or frozen as required by Section 7; the coolant (dry ice, UN 1845) is regulated when used.

15Regulatory information

Regulatory Information

Tsca: Not listed (Cayman: 'Substance is not listed')
Carcinogen Listings: Not listed by IARC, NTP, OSHA, EPA; not on Prop 65
Dea: Not scheduled
Other: WADA: prohibited at all times under S2.2 ('GnRH and its analogues, in males'); PolyPeptide SDS: 'Gonadorelin is on WADA's list of prohibited doping substances (The World Anti-Doping Code): Group S2' - remark only. EU: PolyPeptide notes Directive 92/85/EEC (pregnant/breast-feeding workers) and 'must not be used by persons under 18 years of age'. Approved veterinary drug in the US (Factrel, Cystorelin, Fertagyl; prescription-only) and formerly a human diagnostic.

Carcinogen Listings

No data available.

16Other information

Revision: October 3, 2026
Sources Consulted: Cayman Chemical

PolyPeptide Group

ChemicalBook

Sigma-Aldrich

Sigma-Aldrich / Supelco

MilliporeSigma

Sigma-Aldrich BVBA

Aldrich

American Regent - Sterile Water for Injection, USP

Hospira/Pfizer - Bacteriostatic Water for Injection
Confidence: high
Additional Information: Native GnRH decapeptide. Oral LD50 rat > 3,000 mg/kg, mouse > 4,000 mg/kg (Cayman/PolyPeptide).

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